Although the program is extremely useful to me here at Grove City for note-taking during class, it would only benefit people with access to computers during class. Thus One Note is probably the most useful on college campuses, or in school districts where laptops are provided for every student.
One Note is, however, a really good tool for mathematics. Since math notes usually have a lot of symbols, it is difficult to quickly type up your notes during class. The stylus and One Note provide a simple solution: you can electronically write your notes! The benefits? You can save paper, email your notes, or print your notes. The color choices are great for math notes, and you are even given the option for graph paper grids. I can see my future math students using One Note if they are allowed tablet computers in class. However, if they are not, I as the teacher will still be able to use it. For example, if students had questions about homework at night, I could email them my written solutions.
Below are pictures of different notebooks and then different pages within a notebook:


Here is an example of math notes taken in One Note:
